Telemedicine in Paediatric Subspecialty : A Low Cost Model for Developing Countries during the COVID-19 Pandemic

Background : Telemedicine is the delivery of Health Care Services using information and communication technologies. Most models of Telemedicine in developed countries involve high-cost infrastructure. The COVID-19 pandemic imposed lockdowns and travel restrictions have highlighted the importance and the necessity of an economically viable model of telemedicine for resource-poor countries like India. Methods : We conducted a prospective study to assess the feasibility, acceptability and effectiveness of low-cost model of Telemedicine services for regular follow-up as well as for triaging. A combination of WhatsApp/email using smartphones and Electronic Medical Records (EMR) system was used to provide Telemedicine services. At the end of the e-consult, the patient/ parents were asked to rate their experience on a scale of 0 to 10. Results : A total of 155 children and 865 consults were included. The mean age of the children was 8.5 years. Forty-four consultations were given to 12 (7.7%) International patients. Thirty-eight (24.5%) patients were seen for the first time via Teleconsultation and the remaining 117 (75.5%) were follow-up patients. The most common diagnosis was Nephrotic Syndrome (51.6%) followed by Chronic Kidney Disease (21.9%), Urinary Tract Infection (10.3%), Kidney-transplant follow-up (6.4%), Acute Glomerulonephritis (3.8%), and Acute Kidney Injury (2.6%). Twenty-three patients were advised admission after the Teleconsultation and the remaining 122 children were advised follow-up e-consults. The mean satisfaction score reported for e-consults was 9.4. Conclusion : Our low-cost Telemedicine model offered a viable modality for delivery of Paediatric Nephrology Services during lockdown period and can be replicated by pediatricians practicing other subspecialties as well

Management of steroid resistant nephrotic syndrome.

JUSTIFICATION: There is a lack of evidence based guidelines for management of children with steroid resistant nephrotic syndrome (SRNS). PROCESS: Experts of the Indian Society of Pediatric Nephrology were involved in a two-stage process, the Delphi method followed by a structured face to face meeting, to formulate guidelines, based on current practices and available evidence, on management of these children. Agreement of at least 80% participants formed an opinion. OBJECTIVES: To develop specific, realistic, evidence based criteria for management of children with idiopathic SRNS. RECOMMENDATIONS: The Expert Group emphasized that while all patients with SRNS should initially be referred to a pediatric nephrologist for evaluation, the subsequent care might be collaborative involving the primary pediatrician and the nephrologist. Following the diagnosis of SRNS (lack of remission despite treatment with prednisolone at 2 mg/kg/day for 4 weeks), all patients (with initial or late resistance) should undergo a renal biopsy, before instituting specific treatment. Patients with idiopathic SRNS secondary to minimal change disease or focal segmental glomerulosclerosis should receive similar therapy. Effective regimens include treatment with calcineurin inhibitors (tacrolimus, cyclosporine), intra-venous cyclophosphamide or a combination of pulse corticosteroids with oral cyclophosphamide, and tapering doses of alternate day corticosteroids. Supportive management comprises of, when indicated, therapy with angiotensin converting enzyme inhibitors and statins. It is expected that these guidelines shall enable standardization of care for patients with SRNS in the country.

Does cytokine gene polymorphism affect steroid responses in idiopathic nephrotic syndrome?

Background: Immunological responses may be possibly involved in the pathogenesis of idiopathic nephrotic syndrome (INS). Cytokines act as a potent immunomodulator. Pathogenesis of INS is associated with Th1 and Th2 cytokines imbalance. Aims, Settings and Design: We have investigated the association of IL-4, IL-6, and TNF-alpha gene polymorphisms and analyzed the data to evaluate the effect of these polymorphisms on the pathogenesis and clinical course of INS. Materials and Methods: One hundred fifty children with INS were selected. Children were analyzed for IL-4, IL-6, and TNF-alpha gene polymorphisms by using polymerase chain reaction and restriction fragment length polymorphism. Statistical Analysis Used: Chi-square test was used for different comparisons. The synergistic effects of IL-4, IL-6, and TNF-alpha gene polymorphisms were evaluated by using logistic regression analysis. Results and Conclusions: We compared the steroid-resistant (SR) and steroid-responsive (SS) groups. Our results showed strong association of IL-6 -G174C, and IL-4 -C590T at genotypic level (P = 0.0121, OR = 14.71, 95% CI = 1.59-136.46; and P = 0.0386, OR = 7.29, 95% CI = 1.26-41.69). TNF-alpha revealed a strong association at genotypic level (P = 0.0121, OR = 14.71, 95% CI = 1.59-136.46), as well as at allelic level (P = 0.0433, OR = 2.251, 95% CI = 1.09-4.66), demonstrating that it may be considered one of the genetic risk factors affecting the steroid response in INS patients. The GG genotype of IL-6 -G174C, TT genotype of IL-4 -C590T, and AA genotype of TNF-alpha -G308A cytokine gene polymorphisms may be causative factors for nonresponsiveness towards steroid therapy among INS children.

Plasma infusion therapy in atypical hemolytic uremic syndrome long term outcome.

We report 2 boys with atypical (diarrhea negative) hemolytic uremic syndrome requiring dialysis, who recovered complete renal functions after receiving fresh frozen plasma infusion therapy. One patient relapsed and required second course of plasma infusion therapy. After a prolonged follow up, both showed normal renal functions with mild residual hypertension.

Steroid resistant nephrotic syndrome: role of histopathology.

This study was conducted to (1) see the histopathological distribution of different subtypes in steroid resistant nephrotic syndrome (SRNS) and (2) compare the clinical, biochemical parameters and outcome between Minimal Change Disease (MCD) with non-MCD subtypes in response to immunosuppressive therapy. A retrospective analysis was done of data on all biopsy proven children with idiopathic SRNS (no response to 4 weeks of standard prednisone therapy (60 mg/m(2)/day)) referred to our institute over last 12 years. They were treated with one of the following medications: oral or intravenous cyclophosphamide, cyclosporine or combination of dexamethasone and azathioprine. A comparison was done of the demographic clinical and biochemical features different histopathologies. We studied 136 children with SRNS (100 M, 36 F). They accounted for 15.1%(136/900) of all children with idiopathic nephrotic syndrome. Focal segmental glomerulosclerosis (FSGS) was the commonest 80/136 (59%), followed by MCD (17.6%). Children with non-MCD had a significantly greater prevalence of microhematuria as compared to MCD. The other baseline clinical and biochemical features including the glomerular filtration rate (GFR) were similar. After a mean follow up of 46 (8-148) months, a significantly greater children with non-MCD 65/112) continued to be proteinuric as compared to the MCD (3/24) (p=0.0001). FSGS was the commonest cause of SRNS in our patient population. Children with SRNS secondary to MCD are more likely to achieve remission as compared to non-MCD subtypes and have a better long-term prognosis. Hence kidney biopsy is of significant prognostic value in SRNS.

Hypertension in children.

Abstract. Hypertension is a major public health issue in industrialized nations, affecting approximately 20% of adults. Hypertension often begins in childhood, and children with hypertension are very likely to be seen with this disorder as adults. The close associations of hypertension with atherosclerosis, coronary and cerebrovascular disease, diabetes and end-stage renal disease make it a major contributor to the most common causes of morbidity and mortality in adult population. (1) According to many studies performed in adult populations, the effective treatment of hypertension reduces the risk of coronary heart disease, stroke, renal disease and congestive heart failure. (2)